Analysis of cellular phenotypes that mediate genetic resistance to tuberculosis using a radiation bone marrow chimera approach.

نویسندگان

  • Konstantin B Majorov
  • Evgeny B Eruslanov
  • Elvira I Rubakova
  • Tatiana K Kondratieva
  • Alexander S Apt
چکیده

Adoptive transfer of bone marrow cells from tuberculosis-resistant (I/St x A/Sn)F(1) donor mice into lethally irradiated susceptible I/St recipients changed their phenotype following infection with virulent Mycobacterium tuberculosis. Compared to I/St-->I/St control animals, F(1)-->I/St chimeras demonstrated (i) prolonged survival time, (ii) increased antimycobacterial function of lung macrophages, (iii) elevated gamma interferon production by lung cells, and (iv) decreased infiltration of the lungs with CD4(+) and CD8(+) T cells and Ly-6G(+) neutrophils.

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عنوان ژورنال:
  • Infection and immunity

دوره 73 9  شماره 

صفحات  -

تاریخ انتشار 2005